The Weng Lab is interested in how epigenetics and RNA modifications shape the cell behavior and function, as well as how dysfunction of these mechanisms in response to the genetic and environmental risk factors could be linked to brain disorders. Our main overarching goals are 1) To decipher the role of m6A RNA methylation in establishing, maintaining, and spreading of histone modification domains; 2) To elucidate how risk factors differentially and specifically alter the epigenome/ epitranscriptome/ transcriptional control in neuronal and glial subtypes; 3) To understand the complex reciprocal signaling between neurons and microglia in health and Alzheimer’s disease.
Weng Lab, Houston Methodist Research Institute
6670 Bertner Avenue
Houston, Texas 77030