Welcome to the WENG Lab in the Center for Neuroregeneration in the Department of Neurosurgery at Houston Methodist. Our lab explores the epigenetic and epitranscriptomic mechanisms instructing cell state alterations under physiologic and disease conditions.

Weng Headshot

Yi-Lan Weng, PhD
Assistant Professor of Neurosurgery
Center for Neuroregeneration
Department of Neurosurgery
Neurological Institute
Houston Methodist
Weill Cornell Medical College

The Weng Lab is interested in how epigenetics and RNA modifications shape the cell behavior and function, as well as how dysfunction of these mechanisms in response to the genetic and environmental risk factors could be linked to brain disorders. Our main overarching goals are 1) To decipher the role of m6A RNA methylation in establishing, maintaining, and spreading of histone modification domains; 2) To elucidate how risk factors differentially and specifically alter the epigenome/ epitranscriptome/ transcriptional control in neuronal and glial subtypes; 3) To understand the complex reciprocal signaling between neurons and microglia in health and Alzheimer’s disease.


Weng Lab, Houston Methodist Research Institute
6670 Bertner Avenue
Houston, Texas 77030

Phone: 346-238-5665
Email: wenglab@houstonmethodist.org
Web: weng.hmailabs.org