RNA methylation and regenerative responses
RNA modifications, such as m6A, m1A, inosine (I), m5C, and pseudouridine (Ψ) are widely distributed within the transcriptome, but their roles in neuronal function are largely unknown. We explore the scope and mechanisms underlying dynamic RNA epigenetic regulation in the adult nervous system that could be exploited therapeutically for neural repair and neurological disorders.
We are interested in understating how the transcriptome is differentially compartmentalized in subcellular domains (soma vs. neurite). We are systematically assessing the potency of modified messenger RNA (modRNA) that can localize in axons and promote neuroregeneration.